USMLE step 1

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Breadcrumb Abstract Shape
Breadcrumb Abstract Shape

USMLE Step 1 covers the fundamental medical sciences that form the basis of clinical practice. The main areas include:

Anatomy – gross anatomy, embryology, histology, and neuroanatomy.
Physiology – functions and mechanisms of the organ systems.
Biochemistry & Molecular Biology – metabolism, enzymes, genetics, and molecular pathways.
Pharmacology – drug mechanisms, side effects, and clinical applications.
Pathology – disease mechanisms, organ pathology, and systemic pathology.
Microbiology & Immunology – bacteriology, virology, parasitology, mycology, and the immune response.
Behavioral Sciences – psychology, ethics, physician–patient communication, biostatistics, and epidemiology.
General Principles – nutrition, aging, genetics, and cell biology.

Why MedClarity with Dr. Israa Tarek is Unique

At MedClarity, we simplify the USMLE journey and make it more effective. What makes us unique is our ability to break down complex medical concepts into clear, easy-to-understand explanations.

Our content is presented bilingually (English and Arabic), helping students not only prepare for the exam but also strengthen their academic and language skills. We provide well-structured summaries through charts, mind maps, and ready-to-use PDFs for fast and efficient revision.

Dr. Israa Tarek shares her personal journey and proven strategies for success in international exams, offering students practical guidance and motivation.

The platform is interactive, featuring practice questions, mock exams, and active learning methods to keep students engaged. In addition, MedClarity fosters a supportive community, connecting medical students and doctors from around the world.

Finally, all our material is based on trusted, world-class resources such as First Aid, UWorld, Pathoma, and Sketchy, but presented in a simplified, structured, and easy-to-follow format.

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What Will You Learn?
  • By enrolling in the MedClarity USMLE Step 1 course with Dr. Israa Tarek, students will gain a deep understanding of all core medical subjects tested on Step 1, including:
  • Biochemistry & Molecular Biology – metabolic pathways, enzymes, genetics, and molecular mechanisms.
  • General Pathology – mechanisms of disease, inflammation, tissue repair, neoplasia, and immune-related disorders.
  • Pharmacology – drug mechanisms, therapeutic uses, side effects, and clinical applications.
  • Microbiology & Immunology – bacteria, viruses, fungi, parasites, and host defense mechanisms.
  • Anatomy & Embryology – gross anatomy, neuroanatomy, histology, and developmental biology.
  • Physiology – organ system functions, homeostasis, and integration across systems.
  • Behavioral Sciences & Ethics – psychiatry, communication, professionalism, and epidemiology.
  • Organ Systems Integration – cardiovascular, respiratory, renal, gastrointestinal, reproductive, endocrine, musculoskeletal, skin, and nervous systems with clinical correlations.
  • Additionally, students will develop exam strategies, time management skills, and critical thinking abilities necessary to excel on the USMLE Step 1.

Material Includes

  • The MedClarity USMLE Step 1 course provides comprehensive learning resources to ensure effective preparation:
  • Pre-recorded Video Lectures – Covering all core subjects with clear explanations and clinical correlations.
  • PDF Summaries & Charts – High-yield notes, tables, and diagrams for quick revision.
  • Mind Maps – Visual summaries to help integrate concepts across subjects and organ systems.
  • Practice Questions & Quizzes – Aligned with USMLE Step 1 style, including detailed explanations.
  • Mock Exams – Simulated Step 1 tests to assess progress and exam readiness.
  • Clinical Correlation Cases – Real-life scenarios linking basic sciences to clinical application.
  • Access to Community & Expert Support – Guidance from Dr. Israa Tarek and interaction with fellow students.

Requirements

  • To enroll and succeed in the MedClarity USMLE Step 1 course, students should meet the following requirements:
  • Educational Background: Must be a medical student or graduate with basic knowledge of human biology and pre-clinical sciences.
  • Language Proficiency: Good command of English is recommended, as course materials and lectures are primarily in English.
  • Technology: Access to a computer, tablet, or smartphone with a stable internet connection to view lectures, download materials, and take online quizzes.
  • Study Commitment: Recommended 3–5 hours of focused study per day for 12–16 weeks to complete the full course.
  • Materials Preparation: Students should have a notebook or digital tool for note-taking, and optionally access to reference books like First Aid, Pathoma, and UWorld for further practice.
  • Instructions for Success:
  • Follow the structured course schedule provided in the platform.
  • Watch video lectures first, then review PDFs, charts, and mind maps.
  • Complete practice questions after each topic to reinforce understanding.
  • Take mock exams periodically to assess progress.
  • Engage with Dr. Israa Tarek and the student community for guidance and discussion.

Audience

  • Medical Students: Individuals preparing for the USMLE Step 1 exam who want a structured, efficient, and comprehensive study plan.
  • International Medical Graduates (IMGs): Doctors seeking to strengthen foundational knowledge for Step 1 and improve clinical application skills.
  • Pre-clinical Students: Those looking to solidify their understanding of basic sciences with integrated clinical correlations.
  • Self-Learners: Students who prefer flexible, self-paced study with access to expert guidance and interactive resources.
  • Students Seeking Exam Success Strategies: Anyone wanting proven techniques, summaries, and insights from Dr. Israa Tarek’s personal USMLE experience.

Course Content

Gastrointestinal System
Gastrointestinal Embryology Gastrointestinal Anatomy GI Blood Supply Gastrointestinal Tract Liver, Gallbladder, Pancreas Salivary Glands Hernias Bile Bilirubin Gastrointestinal Secretions Gastrointestinal Hormones Exocrine Pancreas Esophageal Disorders Liver Disease Cirrhosis Liver Tumors Wilson’s & Hemochromatosis Gallstones Biliary Disorders Gastric Disorders Malabsorption Acute Pancreatitis Chronic Pancreatitis & Cancer Intestinal Disorders Inflammatory Bowel Disease Colon Cancer Carcinoid Tumors Gastrointestinal Pharmacology

  • Anatomy
  • Physiology
  • Pathology
  • Pharmacology
  • Embryology
  • UW notes for git

Blood & Lymphoreticular System
Covers hematology and lymphoid tissues. Hematopoiesis and bone marrow Anemias and hemoglobinopathies Coagulation and bleeding disorders Malignancies (leukemia, lymphoma) Drugs for treatments

Cardiovascular System
Focuses on the heart and blood vessels. Cardiac anatomy and physiology Cardiovascular pathology (ischemic heart disease, heart failure, valvular disease) Vascular diseases (hypertension, atherosclerosis, aneurysms) Pharmacology of cardiovascular drugs

Respiratory System
Covers the lungs and airways. Pulmonary anatomy and physiology Gas exchange and acid–base balance Obstructive and restrictive lung diseases Infections and neoplasms of the lung Drugs for treatment

Renal & Urinary System
Covers the kidneys, urinary tract, and fluid balance. Nephron physiology Fluid, electrolyte, and acid–base disorders Glomerular and tubular diseases Renal failure and dialysis concepts Drugs for treatments

Female & Transgender Reproductive System & Breast
Focuses on female reproductive health. Ovarian and uterine physiology Menstrual cycle and hormonal regulation Infertility and reproductive endocrinology Gynecologic cancers Breast physiology and pathology Drugs for treatments

Male & Transgender Reproductive System
Covers male reproductive organs and endocrinology. Testicular physiology and spermatogenesis Prostate diseases Male infertility Sexual development and disorders Drugs for treatments

Endocrine System
Covers hormone-producing glands and metabolism. Hypothalamic–pituitary axis Thyroid and parathyroid function Adrenal gland physiology and pathology Diabetes and metabolic syndrome Cancers Drugs for treatments

Musculoskeletal System
Covers bones, muscles, and connective tissues. Anatomy and physiology of muscles, bones, joints Trauma and fractures Arthritis and connective tissue diseases Muscular dystrophies Drugs for treatments

Skin & Subcutaneous Tissue
Covers dermatology and skin pathology. Structure and function of skin Common dermatologic conditions Skin cancers Infections and inflammatory disorders

Nervous System & Special Senses
Focuses on the brain, spinal cord, and sensory organs. Neuroanatomy and neurophysiology Neurological disorders (stroke, seizures, movement disorders) Ophthalmology and otology basics Special senses: vision, hearing, taste, smell Drugs for treatments

Immune System
Focuses on immunity and disorders of the immune response. Innate and adaptive immunity Immune cells and signaling Immunodeficiency disorders Hypersensitivity and autoimmune diseases Vaccines and cancer treatment

Multisystem Processes & Disorders
Sepsis Shock Autoimmune diseases Genetic disorders

Social Sciences: Communication and Interpersonal Skills
Patient communication Cultural competence Professionalism Ethical considerations

Biostatistics & Epidemiology/Population Health
Study design and statistics Epidemiology Public health principles Screening and prevention

Behavioral Health ( Psychiatry )
Psychiatric disorders Substance use disorders Psychological development Patient–physician communication Medical ethics

General Pathology
Focuses on the fundamental mechanisms of disease that apply to all organ systems. Includes: Cell injury and death (necrosis, apoptosis) Inflammation (acute and chronic) Tissue repair and fibrosis Hemodynamic disorders (edema, thrombosis, shock) Genetic disorders Neoplasia (benign vs malignant, tumor biology) Immunopathology (autoimmune, hypersensitivity)

General Pharmacology
Covers the principles of drug action and basic pharmacokinetics/dynamics. Includes: Pharmacokinetics: absorption, distribution, metabolism, excretion Pharmacodynamics: receptor theory, dose-response relationships Adverse drug reactions and toxicity Drug interactions General principles of antimicrobial, cardiovascular, CNS, and endocrine drugs

Microbiology
Covers microorganisms and host defense mechanisms. Includes: Bacteriology: structure, physiology, pathogenesis, and major pathogens Virology: DNA & RNA viruses, viral life cycles, clinical syndromes Parasitology: protozoa, helminths, and arthropods Mycology: fungi and fungal infections Immunology: innate and adaptive immunity, immune cells, antibodies, cytokines Vaccines and immune-based therapies

Biochemistry
1. Molecular and Cell Biology Structure and function of macromolecules: proteins, nucleic acids, carbohydrates, lipids DNA replication, repair, recombination Transcription and RNA processing Translation, protein synthesis, and post-translational modifications Cell cycle and apoptosis Signal transduction pathways (e.g., GPCRs, tyrosine kinase receptors) 2. Metabolism Carbohydrate metabolism: glycolysis, gluconeogenesis, glycogen metabolism, pentose phosphate pathway Lipid metabolism: fatty acid synthesis and oxidation, ketogenesis, cholesterol metabolism Amino acid metabolism: transamination, urea cycle, catabolism, neurotransmitter synthesis Nucleotide metabolism: purine/pyrimidine synthesis and degradation, salvage pathways Integration and regulation: hormonal control of metabolism (insulin, glucagon, cortisol) 3. Enzymes Enzyme structure and function Kinetics: Michaelis-Menten, Lineweaver-Burk Regulation: allosteric, covalent modification, feedback inhibition Clinical correlations: enzyme deficiencies and inborn errors of metabolism 4. Molecular Genetics Mendelian inheritance patterns Chromosomal abnormalities and cytogenetics Gene expression regulation Epigenetics Population genetics and Hardy-Weinberg principle 5. Nutrition and Vitamins Macronutrients and micronutrients Vitamin and mineral roles and deficiencies Energy balance and metabolic pathways 6. Laboratory Techniques / Clinical Correlation DNA/RNA analysis techniques (PCR, sequencing, hybridization) Enzyme assays Metabolic and genetic disease diagnostics Clinical correlations with metabolic disorders (e.g., PKU, galactosemia, glycogen storage diseases)

USMLE EXAM INTRODUCTION
the most common questions about usmle exam

A course by

IT

Course Includes:

  • Price:
    GEL800.00 GEL1,350.00
  • Instructor:Israa Tarek
  • Duration: 200 hours
  • Lessons:68
  • Students:123
  • Level:Intermediate
GEL800.00 GEL1,350.00
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